|
Retinal Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Resveratrol mitigates rat retinal ischemic injury: the roles of matrix metalloproteinase-9, inducible nitric oxide, and heme oxygenase-1.
|
23075401 |
2013 |
|
Deglutition Disorders
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Intellectual Disability
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Cerebrovascular accident
|
0.030 |
Biomarker
|
group |
BEFREE |
Choline acetyltransferase-positive (ChAT<sup>+</sup>) neurons within the subventricular zone (SVZ) have been shown to promote neurogenesis after stroke in mice by secreting acetylcholine (ACh); however, the mechanisms remain unclear.
|
28551702 |
2017 |
|
Cerebrovascular accident
|
0.030 |
Biomarker
|
group |
BEFREE |
We conclude that ChAT<sup>+</sup> neurons in the SVZ may participate in stroke-induced neurogenesis, suggesting a new mechanism for neurogenesis after stroke.
|
27609645 |
2017 |
|
Cerebrovascular accident
|
0.030 |
Biomarker
|
group |
BEFREE |
This study focused on cholinergic, choline acetyltransferase (ChAT)-immunopositive, and tyrosine hydroxylase (TH)-containing neurons in association with the vasculature to explore the neurovascular complex of the AD brain affected by stroke.
|
28671120 |
2017 |
|
Diabetes Mellitus
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the density of the cholinergic fibers at the surface of the longitudinal muscle was significantly reduced (DM: 24 ± 3%; p = 0.003, control: 41 ± 2%); however, western-blot analysis did not indicate a reduction in the expression of choline acetyltransferase (ChAT) in the DM group.
|
30500400 |
2019 |
|
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
(iii) The numbers of nNOS, CHAT neurons and total neurons in proximal and distal colon were decreased significantly during the course of diabetes (P < 0.05).
|
19709371 |
2009 |
|
Neuromuscular Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (CMS).
|
29311808 |
2017 |
|
Neuromuscular Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Decreases in ChAT activity are associated with a number of disease states, and mutations in ChAT cause congenital neuromuscular disorders.
|
15131697 |
2004 |
|
Congenital Abnormality
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This presentation focuses on the CMS caused by defects in choline acetyltransferase, novel fast-channel syndromes that hinder isomerization of the acetylcholine receptor from the closed to the open state, the consequences of deleterious mutations in the intermediate filament linker plectin, altered neuromuscular transmission in a centronuclear myopathy, and two recently identified CMS caused by congenital defects in glycosylation.
|
23278578 |
2012 |
|
Mental disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our results demonstrated that sequence variants of CHAT were associated with human cognitive ability in not only patients with psychiatric disorders but also normal healthy individuals.
|
26854842 |
2016 |
|
Behavioral Symptoms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Finally, we tested the hypothesis that time-of-day differences in acetylcholinesterase and choline acetyltransferase expression and general neuronal activation (i.e., c-Fos expression) coincide with the behavioral symptoms.
|
21709248 |
2011 |
|
CNS disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Since ChAT::Cre+ rats, used increasingly for understanding the biological basis of CNS disorders, utilize the mouse ChAT promotor to control Cre recombinase expression, we assessed for similar genotypical and phenotypical differences in such rats compared to wild-type siblings.
|
31506825 |
2019 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Furthermore, these mice exhibited the impairment of long-term potentiation in hippocampal CA1 region, and the reduction of hippocampal adenosine-triphosphate content and of choline acetyltransferase-positive neurons in basal forebrain, possibly as pathogenetic factors contributing to the cognitive deficit.
|
21824606 |
2011 |
|
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Compared with the expression in the normal lung tissues, the mRNA and protein expression of ChAT and ChoK increased in nine and 14 of the 18 lung tumors, respectively.
|
25591716 |
2015 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We also detected high levels of choline acetyltransferase in these tumors, which suggests a common neural origin.
|
3390826 |
1988 |
|
Congenital defects
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This presentation focuses on the CMS caused by defects in choline acetyltransferase, novel fast-channel syndromes that hinder isomerization of the acetylcholine receptor from the closed to the open state, the consequences of deleterious mutations in the intermediate filament linker plectin, altered neuromuscular transmission in a centronuclear myopathy, and two recently identified CMS caused by congenital defects in glycosylation.
|
23278578 |
2012 |
|
Motor Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders.
|
15131697 |
2004 |
|
Parkinsonian Disorders
|
0.010 |
Biomarker
|
group |
LHGDN |
Increased ChAT activity was found in CM nuclei in DLB + P compared with DLB - P. These findings show that significant thalamic presynaptic cholinergic deficits occur only in cases of combined cortical and subcortical neurodegeneration in which dementia developed after prolonged parkinsonism.
|
15913843 |
2006 |
|
Pervasive Development Disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Brief Report: Evaluation of the Short Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) as a Brief Screen for Autism Spectrum Disorder in a High-Risk Sibling Cohort.
|
30694516 |
2019 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Choline acetyltransferase (ChAT) is the key enzyme responsible for the synthesis of the neurotransmitter acetylcholine and is reduced in various central neurodegenerative diseases.
|
7682855 |
1993 |
|
Seizures
|
0.410 |
Biomarker
|
phenotype |
BEFREE |
A subset of PPT neurons exhibited reduced firing and hyperpolarization during seizures and stained positive for choline acetyltransferase.
|
30543800 |
2019 |
|
Seizures
|
0.410 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Seizures
|
0.410 |
Biomarker
|
phenotype |
CTD_human |
Our findings suggest that seizures caused cognitive dysfunction and a decrease of ChAT and AChE activities that might be related, at least in part, to the neurological problems presented by seizures induced by pilocarpine.
|
19941057 |
2010 |